Dr Gavin Sacks, Fertility Specialist

MA BM BCh DPhil FRCOG FRANZCOG CCSST (UK subspecialist in Reproductive Medicine)

Clinical Director at IVFAustralia, Staff Specialist at St George Hospital and Royal Hospital for Women, and a Conjoint Associate Professor at UNSW.

Dr Sacks is one of Australia’s leading IVF Specialists and developed ‘The Bondi Protocol’ – immune therapy (prednisolone and clexane) which is affordable, easily accessible and effective in women with high NK cell levels.

Known for his direct and straightforward approach, Dr Sacks believes that there is no ‘one-size fits all treatment package’, and works together with his patients to find the right solution for their unique needs.

Recent Publications and Research

Reproductive Outcomes and General Health in Women with High Natural Killer Cell Levels

The role of natural killer (NK) cells in reproductive failure has been investigated extensively, but the topic remains controversial and poorly understood. NK cells are known to play an important...
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Metformin and PCOS: Potential benefit to reduce miscarriage risk

Polycystic ovary syndrome (PCOS) is associated with an increased risk of miscarriage, occurring in 30% of pregnancies. Although the mechanism is unclear, several interrelated factors appear to...
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A blessing and a curse: is high NK cell activity good for health and bad for reproduction?

Few topics in recent reproductive medicine have been the subject of as much controversy, media attention and passionate debate as natural killer (NK) cells and their role in reproductive failure....
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LH Supplementation for Low LH Levels during Antagonist IVF Cycles Improves Live Birth Rates

Luteinizing hormone (LH) supplementation in IVF cycles has been a debated topic for many years [1-4]. Whilst follicle stimulating hormone (FSH) alone achieves adequate ovarian stimulation it is...
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Enough! Stop the arguments and get on with the science of natural killer cell testing

Natural killer cell testing is currently practised widely, and there are studies indicating potential benefit in terms of targeting women with repeated reproductive failure for immune therapy. This...
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Sperm DNA fragmentation abnormalities in men from couples with a history of recurrent miscarriage.

In this retrospective study, between 2008 and 2013, couples with a history of recurrent miscarriage (≥3 first trimester miscarriages) were investigated comprehensively for known causes (karyotype,...
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Reproductive immunology: the relevance of laboratory research to clinical practice (and vice versa)

In this issue of Human Reproduction, the paper by Gu et al. represents a landmark in reproductive immunology research. A new mechanism for evasion of maternal immune attack is described, one which...
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Single-arm, observational study of the ease of use of a redesigned pen device to deliver recombinant human follicle-stimulating hormone (follitropin alfa) for assisted reproductive technology treatment

Evaluation of patients’ ease of use of the redesigned, disposable, ready-to-use ­follitropin alfa pen during controlled ovarian stimulation for assisted reproductive technology. [download...
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Asynchronous glands in the endometrium of women with recurrent reproductive failure.

Of 969 non-consecutive endometrial biopsies performed for investigation of recurrent reproductive failure, 20 cases (2.1%) showed the striking presence of retarded or asynchronous endometrial glands...
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Recurrent Miscarriage, Investigating the potential causes – published in Medicine Today

Ultimately, investigations will find a cause for recurrent miscarriage in fewer than 50% of affected women. Treatment of the underlying conditions provides hope for success in their next pregnancy....
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Prednisolone for repeated implantation failure associated with high natural killer cell levels.

Women with unexplained repeated IVF failure present a considerable challenge. Some cases are believed to be due to immunological dysfunction preventing effective embryo implantation. As data are...
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The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure. III: Further observations and reference ranges.

Abnormally functioning immunocompetent cells in the endometrium are thought to be responsible for at least some cases of recurrent reproductive failure [recurrent miscarriage or recurrent in vitro...
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